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ea0081rc14.2 | Rapid Communications 14: Late Breaking | ECE2022

Prevention of glucocorticoid-induced adipose dysfunction and hepatic lipid deposition through cold acclimation in aged mice

Gado Manuel , Ghane Zahra , Heinrich Annett , Wiedersich Denise , Bornstein Stefan R , Rauner Martina , Hofbauer Lorenz C , Henneicke Holger

Glucocorticoids (GC) are one of the most potent anti-inflammatory pharmacological agents. However, owing to their pleiotropic nature, their clinical effectiveness is frequently limited by their deleterious off-target effects. Frequently, metabolic abnormalities arise from GC excess involving the development of dyslipidaemia, insulin resistance and muscle atrophy as well as excessive fat accumulation in both white adipose tissue (WAT) and the liver. In addition, suppressed ther...

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ea0073oc12.1 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevention of glucocorticoid-induced adipose dysfunction through selective activation of β3-adrenergic signaling in mice

Gado Manuel , Heinrich Annett , Wiedersich Denise , Noll Monique , Bornstein Stefan R. , Rauner Martina , Hofbauer Lorenz C. , Henneicke Holger

Despite their therapeutic effectiveness, glucocorticoids (GC) clinical usage is frequently limited due to the deleterious metabolic effects. GC-induced obesity arises from excessive fat accumulation in white adipose tissue (WAT) as well as suppressed thermogenic capacity in brown adipose tissue (BAT). Since the sympathetic nervous system (SNS) plays a fundamental role in adipose tissue biology, we examined the interaction between GCs and SNS signaling in the adipose orga...

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Endocrine Abstracts

Prevention of glucocorticoid-induced adipose dysfunction and hepatic lipid deposition through cold acclimation in aged mice

Prevention of glucocorticoid-induced adipose dysfunction through selective activation of β3-adrenergic signaling in mice

BiosciAbstracts